Targeting the DNA Damage Response for Cancer Therapy by Inhibiting the Kinase Wee1

Cancer cells typically heavily rely on the G2/M checkpoint to survive endogenous and exogenous DNA damage, such as genotoxic stress due to genome instability or radiation and chemotherapy. The key regulator of the G2/M checkpoint, the cyclin-dependent kinase 1 (CDK1), is tightly controlled, includin...

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Detalles Bibliográficos
Autores principales: Bukhari, Amirali B., Chan, Gordon K., Gamper, Armin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891215/
https://www.ncbi.nlm.nih.gov/pubmed/35251998
http://dx.doi.org/10.3389/fonc.2022.828684

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891215/
https://www.ncbi.nlm.nih.gov/pubmed/35251998
http://dx.doi.org/10.3389/fonc.2022.828684

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