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Targeting the DNA Damage Response for Cancer Therapy by Inhibiting the Kinase Wee1

Cancer cells typically heavily rely on the G2/M checkpoint to survive endogenous and exogenous DNA damage, such as genotoxic stress due to genome instability or radiation and chemotherapy. The key regulator of the G2/M checkpoint, the cyclin-dependent kinase 1 (CDK1), is tightly controlled, includin...

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Detalles Bibliográficos
Autores principales:	Bukhari, Amirali B., Chan, Gordon K., Gamper, Armin M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891215/ https://www.ncbi.nlm.nih.gov/pubmed/35251998 http://dx.doi.org/10.3389/fonc.2022.828684

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