Downregulation of MUC15 by miR-183-5p.1 promotes liver tumor-initiating cells properties and tumorigenesis via regulating c-MET/PI3K/AKT/SOX2 axis

Mucin 15 (MUC15) is reportedly aberrant in human malignancies, including hepatocellular carcinoma (HCC). However, the role of MUC15 in the regulation of liver tumor-initiating cells (T-ICs) remains unknown. Here, we report that expression of MUC15 is downregulated in liver T-ICs, chemoresistance and...

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Detalles Bibliográficos
Autores principales: Han, Tao, Zheng, Hao, Zhang, Jin, Yang, Pinghua, Li, Hengyu, Cheng, Zhangjun, Xiang, Daimin, Wang, Ruoyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891362/
https://www.ncbi.nlm.nih.gov/pubmed/35236826
http://dx.doi.org/10.1038/s41419-022-04652-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891362/
https://www.ncbi.nlm.nih.gov/pubmed/35236826
http://dx.doi.org/10.1038/s41419-022-04652-9

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