Cargando…
The Potential Protective Effect of Curcumin and α-Lipoic Acid on N-(4-Hydroxyphenyl) Acetamide-induced Hepatotoxicity Through Downregulation of α-SMA and Collagen III Expression
BACKGROUND AND OBJECTIVES: N-(4-hydroxyphenyl) acetamide (NHPA) is the most commonly used analgesic and antipyretic agent worldwide; however, it remains the leading cause of drug-induced acute liver failure. This study explored the potential impact of curcumin (Curc) and/or α-lipoic acid (Lip acid)...
Autores principales: | Alhusain, Ahlam, Fadda, Laila, Sarawi, Wedad, Alomar, Hatun, Ali, Hanaa, Mahamad, Raeesa, Hasan, Iman, Badr, Amira |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8891863/ https://www.ncbi.nlm.nih.gov/pubmed/35250410 http://dx.doi.org/10.1177/15593258221078394 |
Ejemplares similares
-
Nano-Resveratrol: A Promising Candidate for the Treatment of Renal Toxicity Induced by Doxorubicin in Rats Through Modulation of Beclin-1 and mTOR
por: Alhusaini, Ahlam M., et al.
Publicado: (2022) -
Curcumin and Nano-Curcumin Mitigate Copper Neurotoxicity by Modulating Oxidative Stress, Inflammation, and Akt/GSK-3β Signaling
por: Sarawi, Wedad S., et al.
Publicado: (2021) -
Nano-Curcumin Prevents Cardiac Injury, Oxidative Stress and Inflammation, and Modulates TLR4/NF-κB and MAPK Signaling in Copper Sulfate-Intoxicated Rats
por: Sarawi, Wedad S., et al.
Publicado: (2021) -
Nano-Curcumin Prevents Copper Reproductive Toxicity by Attenuating Oxidative Stress and Inflammation and Improving Nrf2/HO-1 Signaling and Pituitary-Gonadal Axis in Male Rats
por: Sarawi, Wedad S., et al.
Publicado: (2022) -
A novel pipeline of 2-(benzenesulfonamide)-N-(4-hydroxyphenyl) acetamide analgesics that lack hepatotoxicity and retain antipyresis
por: Bazan, Hernan A., et al.
Publicado: (2020)