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Metabolic regulation of ferroptosis in the tumor microenvironment

Ferroptosis is an iron-dependent, nonapoptotic form of regulated cell death triggered by impaired redox and antioxidant machinery and propagated by the accumulation of toxic lipid peroxides. A compendium of experimental studies suggests that ferroptosis is tumor-suppressive. Sensitivity or resistanc...

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Detalles Bibliográficos
Autores principales: Mbah, Nneka E., Lyssiotis, Costas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892088/
https://www.ncbi.nlm.nih.gov/pubmed/35065965
http://dx.doi.org/10.1016/j.jbc.2022.101617
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author Mbah, Nneka E.
Lyssiotis, Costas A.
author_facet Mbah, Nneka E.
Lyssiotis, Costas A.
author_sort Mbah, Nneka E.
collection PubMed
description Ferroptosis is an iron-dependent, nonapoptotic form of regulated cell death triggered by impaired redox and antioxidant machinery and propagated by the accumulation of toxic lipid peroxides. A compendium of experimental studies suggests that ferroptosis is tumor-suppressive. Sensitivity or resistance to ferroptosis can be regulated by cell-autonomous and non-cell-autonomous metabolic mechanisms. This includes a role for ferroptosis that extends beyond the tumor cells themselves, mediated by components of the tumor microenvironment, including T cells and other immune cells. Herein, we review the intrinsic and extrinsic factors that promote the sensitivity of cancer cells to ferroptosis and conclude by describing approaches to harness the full utility of ferroptotic agents as therapeutic options for cancer therapy.
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spelling pubmed-88920882022-03-10 Metabolic regulation of ferroptosis in the tumor microenvironment Mbah, Nneka E. Lyssiotis, Costas A. J Biol Chem JBC Reviews Ferroptosis is an iron-dependent, nonapoptotic form of regulated cell death triggered by impaired redox and antioxidant machinery and propagated by the accumulation of toxic lipid peroxides. A compendium of experimental studies suggests that ferroptosis is tumor-suppressive. Sensitivity or resistance to ferroptosis can be regulated by cell-autonomous and non-cell-autonomous metabolic mechanisms. This includes a role for ferroptosis that extends beyond the tumor cells themselves, mediated by components of the tumor microenvironment, including T cells and other immune cells. Herein, we review the intrinsic and extrinsic factors that promote the sensitivity of cancer cells to ferroptosis and conclude by describing approaches to harness the full utility of ferroptotic agents as therapeutic options for cancer therapy. American Society for Biochemistry and Molecular Biology 2022-01-21 /pmc/articles/PMC8892088/ /pubmed/35065965 http://dx.doi.org/10.1016/j.jbc.2022.101617 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle JBC Reviews
Mbah, Nneka E.
Lyssiotis, Costas A.
Metabolic regulation of ferroptosis in the tumor microenvironment
title Metabolic regulation of ferroptosis in the tumor microenvironment
title_full Metabolic regulation of ferroptosis in the tumor microenvironment
title_fullStr Metabolic regulation of ferroptosis in the tumor microenvironment
title_full_unstemmed Metabolic regulation of ferroptosis in the tumor microenvironment
title_short Metabolic regulation of ferroptosis in the tumor microenvironment
title_sort metabolic regulation of ferroptosis in the tumor microenvironment
topic JBC Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892088/
https://www.ncbi.nlm.nih.gov/pubmed/35065965
http://dx.doi.org/10.1016/j.jbc.2022.101617
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