Nanobodies as allosteric modulators of Parkinson’s disease–associated LRRK2

Mutations in the gene coding for leucine-rich repeat kinase 2 (LRRK2) are a leading cause of the inherited form of Parkinson’s disease (PD), while LRRK2 overactivation is also associated with the more common idiopathic form of PD. LRRK2 is a large multidomain protein, including a GTPase as well as a...

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Detalles Bibliográficos
Autores principales: Singh, Ranjan K., Soliman, Ahmed, Guaitoli, Giambattista, Störmer, Eliza, von Zweydorf, Felix, Dal Maso, Thomas, Oun, Asmaa, Van Rillaer, Laura, Schmidt, Sven H., Chatterjee, Deep, David, Joshua A., Pardon, Els, Schwartz, Thomas U., Knapp, Stefan, Kennedy, Eileen J., Steyaert, Jan, Herberg, Friedrich W., Kortholt, Arjan, Gloeckner, Christian Johannes, Versées, Wim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892280/
https://www.ncbi.nlm.nih.gov/pubmed/35217606
http://dx.doi.org/10.1073/pnas.2112712119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892280/
https://www.ncbi.nlm.nih.gov/pubmed/35217606
http://dx.doi.org/10.1073/pnas.2112712119

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