A DNA repair-independent role for alkyladenine DNA glycosylase in alkylation-induced unfolded protein response

Alkylating agents damage DNA and proteins and are widely used in cancer chemotherapy. While cellular responses to alkylation-induced DNA damage have been explored, knowledge of how alkylation affects global cellular stress responses is sparse. Here, we examined the effects of the alkylating agent me...

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Detalles Bibliográficos
Autores principales: Milano, Larissa, Charlier, Clara F., Andreguetti, Rafaela, Cox, Thomas, Healing, Eleanor, Thomé, Marcos P., Elliott, Ruan M., Samson, Leona D., Masson, Jean-Yves, Lenz, Guido, Henriques, João Antonio P., Nohturfft, Axel, Meira, Lisiane B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892324/
https://www.ncbi.nlm.nih.gov/pubmed/35197283
http://dx.doi.org/10.1073/pnas.2111404119

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