NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer

Evasion from drug-induced apoptosis is a crucial mechanism of cancer treatment resistance. The proapoptotic protein NOXA marks an aggressive pancreatic ductal adenocarcinoma (PDAC) subtype. To identify drugs that unleash the death-inducing potential of NOXA, we performed an unbiased drug screening e...

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Detalles Bibliográficos
Autores principales: Doffo, Josefina, Bamopoulos, Stefanos A., Köse, Hazal, Orben, Felix, Zang, Chuanbing, Pons, Miriam, den Dekker, Alexander T., Brouwer, Rutger W. W., Baluapuri, Apoorva, Habringer, Stefan, Reichert, Maximillian, Illendula, Anuradha, Krämer, Oliver H., Schick, Markus, Wolf, Elmar, van IJcken, Wilfred F. J., Esposito, Irene, Keller, Ulrich, Schneider, Günter, Wirth, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892327/
https://www.ncbi.nlm.nih.gov/pubmed/35197278
http://dx.doi.org/10.1073/pnas.2105691119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892327/
https://www.ncbi.nlm.nih.gov/pubmed/35197278
http://dx.doi.org/10.1073/pnas.2105691119

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