Targeting stem-loop 1 of the SARS-CoV-2 5′ UTR to suppress viral translation and Nsp1 evasion

SARS-CoV-2 is a highly pathogenic virus that evades antiviral immunity by interfering with host protein synthesis, mRNA stability, and protein trafficking. The SARS-CoV-2 nonstructural protein 1 (Nsp1) uses its C-terminal domain to block the messenger RNA (mRNA) entry channel of the 40S ribosome to...

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Detalles Bibliográficos
Autores principales: Vora, Setu M., Fontana, Pietro, Mao, Tianyang, Leger, Valerie, Zhang, Ying, Fu, Tian-Min, Lieberman, Judy, Gehrke, Lee, Shi, Ming, Wang, Longfei, Iwasaki, Akiko, Wu, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892331/
https://www.ncbi.nlm.nih.gov/pubmed/35149555
http://dx.doi.org/10.1073/pnas.2117198119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892331/
https://www.ncbi.nlm.nih.gov/pubmed/35149555
http://dx.doi.org/10.1073/pnas.2117198119

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