Cargando…

Targeting stem-loop 1 of the SARS-CoV-2 5′ UTR to suppress viral translation and Nsp1 evasion

SARS-CoV-2 is a highly pathogenic virus that evades antiviral immunity by interfering with host protein synthesis, mRNA stability, and protein trafficking. The SARS-CoV-2 nonstructural protein 1 (Nsp1) uses its C-terminal domain to block the messenger RNA (mRNA) entry channel of the 40S ribosome to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vora, Setu M., Fontana, Pietro, Mao, Tianyang, Leger, Valerie, Zhang, Ying, Fu, Tian-Min, Lieberman, Judy, Gehrke, Lee, Shi, Ming, Wang, Longfei, Iwasaki, Akiko, Wu, Hao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892331/ https://www.ncbi.nlm.nih.gov/pubmed/35149555 http://dx.doi.org/10.1073/pnas.2117198119

Ejemplares similares

SARS-CoV-2 Nsp1 suppresses host but not viral translation through a bipartite mechanism
por: Shi, Ming, et al.
Publicado: (2020)

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2
por: Thoms, Matthias, et al.
Publicado: (2020)

Inflammasome activation at the crux of severe COVID-19
por: Vora, Setu M., et al.
Publicado: (2021)

Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein
por: Hsu, Jack Chun-Chieh, et al.
Publicado: (2021)

Structural and Biological Basis of Alphacoronavirus nsp1 Associated with Host Proliferation and Immune Evasion
por: Shen, Zhou, et al.
Publicado: (2020)

Extended ensemble simulations of a SARS-CoV-2 nsp1–5’-UTR complex
por: Sakuraba, Shun, et al.
Publicado: (2022)

Correlated sequence signatures are present within the genomic 5′UTR RNA and NSP1 protein in coronaviruses
por: Sosnowski, Piotr, et al.
Publicado: (2022)

A small stem-loop-forming region within the 3′-UTR of a nonpolyadenylated LCMV mRNA promotes translation
por: Hashizume, Mei, et al.
Publicado: (2022)

Universal features of Nsp1-mediated translational shutdown by coronaviruses
por: Schubert, Katharina, et al.
Publicado: (2023)

Structural Lability in Stem–Loop 1 Drives a 5′ UTR–3′ UTR Interaction in Coronavirus Replication
por: Li, Lichun, et al.
Publicado: (2008)

Molecular dynamic simulations reveal anti-SARS-CoV-2 activity of mitocurcumin by potentially blocking innate immune evasion proteins NSP3 and NSP16
por: Pal, Debojyoti, et al.
Publicado: (2022)

Disruption of TWIST1 translation by 5′ UTR variants in Saethre‐Chotzen syndrome
por: Zhou, Yan, et al.
Publicado: (2018)

Translational control by 3′-UTR-binding proteins
por: Szostak, Emilia, et al.
Publicado: (2013)

Immunogenic and antigenic analysis of recombinant NSP1 and NSP11 of PRRS virus
por: Contreras‐Luna, María Josefina, et al.
Publicado: (2022)

Nutrient regulation of lipochitooligosaccharide recognition in plants via NSP1 and NSP2
por: Li, Xin-Ran, et al.
Publicado: (2022)

Translational Control of Immune Evasion in Cancer
por: Suresh, Shruthy, et al.
Publicado: (2021)

Inhibition of translation and immune responses by the virulence factor Nsp1 of SARS-CoV-2
por: Vann, Kendra R., et al.
Publicado: (2020)

Lost in translation: The 3'-UTR of IGF1R as an ancient long noncoding RNA
por: Mainieri, Avantika, et al.
Publicado: (2018)

A Correlation between 3′-UTR of OXA1 Gene and Yeast Mitochondrial Translation
por: Hajikarimlou, Maryam, et al.
Publicado: (2023)

Effects of Mutagenesis of Murine Hepatitis Virus NSP1 and NSP14 on Replication in Culture
por: Eckerle, Lance D., et al.
Publicado: (2006)

Before It Gets Started: Regulating Translation at the 5′ UTR
por: Araujo, Patricia R., et al.
Publicado: (2012)

Frequency of HLA‑G UTR‑1/UTR‑3/UTR‑7 in women with unexplained recurrent spontaneous abortion
por: Bai, Wei, et al.
Publicado: (2022)

Type I and Type III Interferons – Induction, Signaling, Evasion, and Application to Combat COVID-19
por: Park, Annsea, et al.
Publicado: (2020)

Order and disorder bound together in SARS-CoV-2 Nsp1 suppress host translation
por: Libich, David S., et al.
Publicado: (2023)

All Domains of SARS-CoV-2 nsp1 Determine Translational Shutoff and Cytotoxicity of the Protein
por: Frolov, Ilya, et al.
Publicado: (2023)

SARS-CoV-2 Nsp1 regulates translation start site fidelity to promote infection
por: Aviner, Ranen, et al.
Publicado: (2023)

The Life and Death of Anaplasma
por: Vora, Setu
Publicado: (2011)

Cell Morphogenesis Proteins Are Translationally Controlled through UTRs by the Ndr/LATS Target Ssd1
por: Wanless, Antony G., et al.
Publicado: (2014)

Global 5′-UTR RNA structure regulates translation of a SERPINA1 mRNA
por: Grayeski, Philip J, et al.
Publicado: (2022)

Coronavirus NSP6 protein (nsp6)
Publicado: (2014)

Stabilization of SMAR1 mRNA by PGA2 involves a stem–loop structure in the 5′ UTR
por: Pavithra, Lakshminarasimhan, et al.
Publicado: (2007)

Stem-Loop 1 in the 5’ UTR of the Sars Coronavirus can Substitute for its Counterpart in Mouse Hepatitis Virus
por: Kang, Hyojeung, et al.
Publicado: (2006)

Cap-independent translation through the p27 5′-UTR
por: Jiang, Hong, et al.
Publicado: (2007)

5′-UTR RNA G-quadruplexes: translation regulation and targeting
por: Bugaut, Anthony, et al.
Publicado: (2012)

5′-UTR G-quadruplex structures acting as translational repressors
por: Beaudoin, Jean-Denis, et al.
Publicado: (2010)

The Genomic 3′ UTR of Flaviviruses Is a Translation Initiation Enhancer
por: Berzal-Herranz, Alfredo, et al.
Publicado: (2022)

The key features of SARS-CoV-2 leader and NSP1 required for viral escape of NSP1-mediated repression
por: Bujanic, Lucija, et al.
Publicado: (2022)

Functional analysis of the stem loop S3 and S4 structures in the coronavirus 3′UTR
por: Liu, Pinghua, et al.
Publicado: (2013)

The 5′UTR-intron of the Gladiolus polyubiquitin promoter GUBQ1 enhances translation efficiency in Gladiolus and Arabidopsis
por: Kamo, Kathryn, et al.
Publicado: (2012)

The helicase Ded1p controls use of near-cognate translation initiation codons in 5′UTRs
por: Guenther, Ulf-Peter, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_hfkmojec4qthkh6ndaoot8q7at