Dephosphorylation accelerates the dissociation of ZAP70 from the T cell receptor

Protein–protein binding domains are critical in signaling networks. Src homology 2 (SH2) domains are binding domains that interact with sequences containing phosphorylated tyrosines. A subset of SH2 domain–containing proteins has tandem domains, which are thought to enhance binding affinity and spec...

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Detalles Bibliográficos
Autores principales: Goyette, Jesse, Depoil, David, Yang, Zhengmin, Isaacson, Samuel A., Allard, Jun, van der Merwe, P. Anton, Gaus, Katharina, Dustin, Michael L., Dushek, Omer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892339/
https://www.ncbi.nlm.nih.gov/pubmed/35197288
http://dx.doi.org/10.1073/pnas.2116815119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892339/
https://www.ncbi.nlm.nih.gov/pubmed/35197288
http://dx.doi.org/10.1073/pnas.2116815119

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