Evolutionarily conserved inhibitory uORFs sensitize Hox mRNA translation to start codon selection stringency

Translation start site selection in eukaryotes is influenced by context nucleotides flanking the AUG codon and by levels of the eukaryotic translation initiation factors eIF1 and eIF5. In a search of mammalian genes, we identified five homeobox (Hox) gene paralogs initiated by AUG codons in conserve...

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Detalles Bibliográficos
Autores principales: Ivanov, Ivaylo P., Saba, James A., Fan, Chen-Ming, Wang, Ji, Firth, Andrew E., Cao, Chune, Green, Rachel, Dever, Thomas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892498/
https://www.ncbi.nlm.nih.gov/pubmed/35217614
http://dx.doi.org/10.1073/pnas.2117226119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892498/
https://www.ncbi.nlm.nih.gov/pubmed/35217614
http://dx.doi.org/10.1073/pnas.2117226119

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