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Evolutionarily conserved inhibitory uORFs sensitize Hox mRNA translation to start codon selection stringency
Translation start site selection in eukaryotes is influenced by context nucleotides flanking the AUG codon and by levels of the eukaryotic translation initiation factors eIF1 and eIF5. In a search of mammalian genes, we identified five homeobox (Hox) gene paralogs initiated by AUG codons in conserve...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892498/ https://www.ncbi.nlm.nih.gov/pubmed/35217614 http://dx.doi.org/10.1073/pnas.2117226119 |