Abolishing the prelamin A ZMPSTE24 cleavage site leads to progeroid phenotypes with near-normal longevity in mice

Prelamin A is a farnesylated precursor of lamin A, a nuclear lamina protein. Accumulation of the farnesylated prelamin A variant progerin, with an internal deletion including its processing site, causes Hutchinson–Gilford progeria syndrome. Loss-of-function mutations in ZMPSTE24, which encodes the p...

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Detalles Bibliográficos
Autores principales: Wang, Yuexia, Shilagardi, Khurts, Hsu, Trunee, Odinammadu, Kamsi O., Maruyama, Takamitsu, Wu, Wei, Lin, Chyuan-Sheng, Damoci, Christopher B., Spear, Eric D., Shin, Ji-Yeon, Hsu, Wei, Michaelis, Susan, Worman, Howard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892526/
https://www.ncbi.nlm.nih.gov/pubmed/35197292
http://dx.doi.org/10.1073/pnas.2118695119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892526/
https://www.ncbi.nlm.nih.gov/pubmed/35197292
http://dx.doi.org/10.1073/pnas.2118695119

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