Fe-S cofactors in the SARS-CoV-2 RNA-dependent RNA polymerase are potential antiviral targets

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of COVID-19, uses an RNA-dependent RNA polymerase (RdRp) for the replication of its genome and the transcription of its genes. We found that the catalytic subunit of the RdRp, nsp12, ligates two iron-sulfur metal cofactor...

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Detalles Bibliográficos
Autores principales: Maio, Nunziata, Lafont, Bernard A. P., Sil, Debangsu, Li, Yan, Bollinger, J. Martin, Krebs, Carsten, Pierson, Theodore C., Linehan, W. Marston, Rouault, Tracey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892629/
https://www.ncbi.nlm.nih.gov/pubmed/34083449
http://dx.doi.org/10.1126/science.abi5224

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892629/
https://www.ncbi.nlm.nih.gov/pubmed/34083449
http://dx.doi.org/10.1126/science.abi5224

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