Microglial VPS35 deficiency impairs Aβ phagocytosis and Aβ-induced disease-associated microglia, and enhances Aβ associated pathology

BACKGROUND: Vacuolar sorting protein 35 (VPS35), a key component of the retromer, plays an essential role in selectively retrieval of transmembrane proteins from endosomes to trans-Golgi networks. Dysfunctional retromer is a risk factor for neurodegenerative disorders, including Alzheimer’s disease...

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Detalles Bibliográficos
Autores principales: Ren, Xiao, Yao, Lingling, Wang, YongGang, Mei, Lin, Xiong, Wen-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892702/
https://www.ncbi.nlm.nih.gov/pubmed/35236374
http://dx.doi.org/10.1186/s12974-022-02422-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892702/
https://www.ncbi.nlm.nih.gov/pubmed/35236374
http://dx.doi.org/10.1186/s12974-022-02422-0

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