Cargando…

Microglial VPS35 deficiency impairs Aβ phagocytosis and Aβ-induced disease-associated microglia, and enhances Aβ associated pathology

BACKGROUND: Vacuolar sorting protein 35 (VPS35), a key component of the retromer, plays an essential role in selectively retrieval of transmembrane proteins from endosomes to trans-Golgi networks. Dysfunctional retromer is a risk factor for neurodegenerative disorders, including Alzheimer’s disease...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ren, Xiao, Yao, Lingling, Wang, YongGang, Mei, Lin, Xiong, Wen-Cheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892702/ https://www.ncbi.nlm.nih.gov/pubmed/35236374 http://dx.doi.org/10.1186/s12974-022-02422-0

Ejemplares similares

Microglial VPS35 deficiency regulates microglial polarization and decreases ischemic stroke-induced damage in the cortex
por: Ye, Shi-Yang, et al.
Publicado: (2019)

Transcriptional signature in microglia associated with Aβ plaque phagocytosis
por: Grubman, Alexandra, et al.
Publicado: (2021)

Peli1 impairs microglial Aβ phagocytosis through promoting C/EBPβ degradation
por: Xu, Jing, et al.
Publicado: (2020)

Distinct modulation of microglial amyloid β phagocytosis and migration by neuropeptides(i)
por: Fleisher-Berkovich, Sigal, et al.
Publicado: (2010)

Cromolyn Reduces Levels of the Alzheimer’s Disease-Associated Amyloid β-Protein by Promoting Microglial Phagocytosis
por: Zhang, Can, et al.
Publicado: (2018)

Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease
por: Pan, Xiao-dong, et al.
Publicado: (2011)

Effects of Immunomodulatory Substances on Phagocytosis of Aβ (1–42) by Human Microglia
por: Hjorth, Erik, et al.
Publicado: (2010)

Coupling of terminal differentiation deficit with neurodegenerative pathology in Vps35-deficient pyramidal neurons
por: Tang, Fu-Lei, et al.
Publicado: (2020)

Neuropeptide Y inhibits interleukin-1β-induced phagocytosis by microglial cells
por: Ferreira, Raquel, et al.
Publicado: (2011)

Alginate-Derived Oligosaccharide Inhibits Neuroinflammation and Promotes Microglial Phagocytosis of β-Amyloid
por: Zhou, Rui, et al.
Publicado: (2015)

Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis
por: Sierra, Amanda, et al.
Publicado: (2013)

DSCR1 deficiency ameliorates the Aβ pathology of Alzheimer’s disease by enhancing microglial activity
por: Choi, Chiyeol, et al.
Publicado: (2022)

Accelerated microglial pathology is associated with Aβ plaques in mouse models of Alzheimer’s disease
por: Baron, Rona, et al.
Publicado: (2014)

Vps35-deficiency impairs SLC4A11 trafficking and promotes corneal dystrophy
por: Liu, Wei, et al.
Publicado: (2017)

Neuronal Death Induced by Nanomolar Amyloid β Is Mediated by Primary Phagocytosis of Neurons by Microglia
por: Neniskyte, Urte, et al.
Publicado: (2011)

Antiretroviral medications disrupt microglial phagocytosis of β-amyloid and increase its production by neurons: Implications for HIV-associated neurocognitive disorders
por: Giunta, Brian, et al.
Publicado: (2011)

Replicative senescence dictates the emergence of disease-associated microglia and contributes to Aβ pathology
por: Hu, Yanling, et al.
Publicado: (2021)

Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of β-amyloid
por: Rubio-Araiz, Ana, et al.
Publicado: (2018)

VPS35-deficiency results in an impaired AMPA receptor trafficking and decreased dendritic spine maturation
por: Tian, Yun, et al.
Publicado: (2015)

Efavirenz Promotes β-Secretase Expression and Increased Aβ(1-40,42) via Oxidative Stress and Reduced Microglial Phagocytosis: Implications for HIV Associated Neurocognitive Disorders (HAND)
por: Brown, Lecia A. M., et al.
Publicado: (2014)

Inhibition of microglial β-glucocerebrosidase hampers the microglia-mediated antioxidant and protective response in neurons
por: Brunialti, Electra, et al.
Publicado: (2021)

Manganese Exposure Aggravates β-Amyloid Pathology by Microglial Activation
por: Lin, Geng, et al.
Publicado: (2020)

Polysaccharides from Ganoderma lucidum attenuate microglia-mediated neuroinflammation and modulate microglial phagocytosis and behavioural response
por: Cai, Qing, et al.
Publicado: (2017)

Folate Deficiency Increased Microglial Amyloid-β Phagocytosis via the RAGE Receptor in Chronic Unpredictable Mild-Stress Rat and BV2 Cells
por: Fan, Junting, et al.
Publicado: (2023)

Primary phagocytosis of viable neurons by microglia activated with LPS or Aβ is dependent on calreticulin/LRP phagocytic signalling
por: Fricker, Michael, et al.
Publicado: (2012)

VISTA regulates microglia homeostasis and myelin phagocytosis, and is associated with MS lesion pathology
por: Borggrewe, Malte, et al.
Publicado: (2021)

Microglial Amyloid-β1-40 Phagocytosis Dysfunction Is Caused by High-Mobility Group Box Protein-1: Implications for the Pathological Progression of Alzheimer's Disease
por: Takata, Kazuyuki, et al.
Publicado: (2012)

Expression of Low Level of VPS35-mCherry Fusion Protein Diminishes Vps35 Depletion Induced Neuron Terminal Differentiation Deficits and Neurodegenerative Pathology, and Prevents Neonatal Death
por: Zhao, Yang, et al.
Publicado: (2021)

The CD33 short isoform is a gain-of-function variant that enhances Aβ(1–42) phagocytosis in microglia
por: Bhattacherjee, Abhishek, et al.
Publicado: (2021)

Central nervous system diseases related to pathological microglial phagocytosis
por: Wang, Ke, et al.
Publicado: (2021)

A Maitake (Grifola frondosa) polysaccharide ameliorates Alzheimer's disease-like pathology and cognitive impairments by enhancing microglial amyloid-β clearance
por: Bai, Yao, et al.
Publicado: (2019)

TREM2 promotes Aβ phagocytosis by upregulating C/EBPα-dependent CD36 expression in microglia
por: Kim, Su-Man, et al.
Publicado: (2017)

Roles of Microglial and Monocyte Chemokines and Their Receptors in Regulating Alzheimer's Disease-Associated Amyloid-β and Tau Pathologies
por: Guedes, Joana R., et al.
Publicado: (2018)

Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy
por: Zavodszky, Eszter, et al.
Publicado: (2014)

(D620N) VPS35 causes the impairment of Wnt/β-catenin signaling cascade and mitochondrial dysfunction in a PARK17 knockin mouse model
por: Chiu, Ching-Chi, et al.
Publicado: (2020)

EhVps32 Is a Vacuole-Associated Protein Involved in Pinocytosis and Phagocytosis of Entamoeaba histolytica
por: Avalos-Padilla, Yunuen, et al.
Publicado: (2015)

Neu1 Is Released From Activated Microglia, Stimulating Microglial Phagocytosis and Sensitizing Neurons to Glutamate
por: Allendorf, David H., et al.
Publicado: (2022)

LRPAP1 is released from activated microglia and inhibits microglial phagocytosis and amyloid beta aggregation
por: Reid, Kyle M., et al.
Publicado: (2023)

Vps35 Deficiency Impairs Cdk5/p35 Degradation and Promotes the Hyperphosphorylation of Tau Protein in Retinal Ganglion Cells
por: Gao, Ling, et al.
Publicado: (2020)

A cortical immune network map identifies distinct microglial transcriptional programs associated with β-amyloid and Tau pathologies
por: Patrick, Ellis, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_s42vtg2ks53iu86hpjunjuj3up