Cleavage of Abasic Sites in DNA by an Aminoquinoxaline Compound: Augmented Cytotoxicity and DNA Damage in Combination with an Anticancer Drug Chlorambucil in Human Colorectal Carcinoma Cells

[Image: see text] The elevated level of endogenous oxidative DNA damage and spontaneous deamination of DNA bases in cancer cells substantially increase the abasic sites in DNA via base excision repairs (BERs). Thus, the predominant BER pathway is a favorable target for cancer therapy. Interestingly,...

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Detalles Bibliográficos
Autores principales: Mandi, Chandra Sova, Mahata, Tridib, Patra, Dipendu, Chakraborty, Jeet, Bora, Achyut, Pal, Ritesh, Dutta, Sanjay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892855/
https://www.ncbi.nlm.nih.gov/pubmed/35252645
http://dx.doi.org/10.1021/acsomega.1c04962

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892855/
https://www.ncbi.nlm.nih.gov/pubmed/35252645
http://dx.doi.org/10.1021/acsomega.1c04962

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