High-Throughput Imaging of CRISPR- and Recombinant Adeno-Associated Virus–Induced DNA Damage Response in Human Hematopoietic Stem and Progenitor Cells

CRISPR-Cas technology has revolutionized gene editing, but concerns remain due to its propensity for off-target interactions. This, combined with genotoxicity related to both CRISPR-Cas9-induced double-strand breaks and transgene delivery, poses a significant liability for clinical genome-editing ap...

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Detalles Bibliográficos
Autores principales: Allen, Daniel, Weiss, Lucien E., Saguy, Alon, Rosenberg, Michael, Iancu, Ortal, Matalon, Omri, Lee, Ciaran, Beider, Katia, Nagler, Arnon, Shechtman, Yoav, Hendel, Ayal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892977/
https://www.ncbi.nlm.nih.gov/pubmed/35049367
http://dx.doi.org/10.1089/crispr.2021.0128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892977/
https://www.ncbi.nlm.nih.gov/pubmed/35049367
http://dx.doi.org/10.1089/crispr.2021.0128

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