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High-Throughput Imaging of CRISPR- and Recombinant Adeno-Associated Virus–Induced DNA Damage Response in Human Hematopoietic Stem and Progenitor Cells

CRISPR-Cas technology has revolutionized gene editing, but concerns remain due to its propensity for off-target interactions. This, combined with genotoxicity related to both CRISPR-Cas9-induced double-strand breaks and transgene delivery, poses a significant liability for clinical genome-editing ap...

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Detalles Bibliográficos
Autores principales:	Allen, Daniel, Weiss, Lucien E., Saguy, Alon, Rosenberg, Michael, Iancu, Ortal, Matalon, Omri, Lee, Ciaran, Beider, Katia, Nagler, Arnon, Shechtman, Yoav, Hendel, Ayal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc., publishers 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892977/ https://www.ncbi.nlm.nih.gov/pubmed/35049367 http://dx.doi.org/10.1089/crispr.2021.0128

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