CRISPR/Cas9 unveils the dynamics of the endogenous µ‐opioid receptors on neuronal cells under continuous opioid stimulation

Long‐term opioid use develops tolerance and attenuates analgesic effects. Upon activation, µ‐opioid receptors (MOPs) are internalized and directed to either recycling or degradation pathway. Ligand stimulation also promotes de novo MOP synthesis. These processes collaboratively regulate MOP expressi...

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Detalles Bibliográficos
Autores principales: Shimizu, Satoshi, Shiraki, Atsuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893010/
https://www.ncbi.nlm.nih.gov/pubmed/35239244
http://dx.doi.org/10.1002/prp2.933

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893010/
https://www.ncbi.nlm.nih.gov/pubmed/35239244
http://dx.doi.org/10.1002/prp2.933

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