Natural and Synthetic Suppressor Mutations Defy Stability–Activity Tradeoffs

[Image: see text] Thermodynamic stability represents one important constraint on protein evolution, but the molecular basis for how mutations that change stability impact fitness remains unclear. Here, we demonstrate that a prevalent global suppressor mutation in TEM β-lactamase, M182T, increases fi...

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Detalles Bibliográficos
Autores principales: Lee, Sonya, Okoye, Cynthia N., Biesbrock, Devin, Harris, Emily C., Miyasaki, Katelyn F., Rilinger, Ryan G., Tso, Megalan, Hart, Kathryn M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893143/
https://www.ncbi.nlm.nih.gov/pubmed/35142509
http://dx.doi.org/10.1021/acs.biochem.1c00805

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893143/
https://www.ncbi.nlm.nih.gov/pubmed/35142509
http://dx.doi.org/10.1021/acs.biochem.1c00805

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