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Natural and Synthetic Suppressor Mutations Defy Stability–Activity Tradeoffs
[Image: see text] Thermodynamic stability represents one important constraint on protein evolution, but the molecular basis for how mutations that change stability impact fitness remains unclear. Here, we demonstrate that a prevalent global suppressor mutation in TEM β-lactamase, M182T, increases fi...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893143/ https://www.ncbi.nlm.nih.gov/pubmed/35142509 http://dx.doi.org/10.1021/acs.biochem.1c00805 |