A Cysteine Variant at an Allosteric Site Alters MIF Dynamics and Biological Function in Homo- and Heterotrimeric Assemblies

Macrophage migration inhibitory factor (MIF) is an inflammatory protein with various non-overlapping functions. It is not only conserved in mammals, but it is found in parasites, fish, and plants. Human MIF is a homotrimer with an enzymatic cavity between two subunits with Pro1 as a catalytic base,...

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Detalles Bibliográficos
Autores principales: Skeens, Erin, Pantouris, Georgios, Shah, Dilip, Manjula, Ramu, Ombrello, Michael J., Maluf, N. Karl, Bhandari, Vineet, Lisi, George P., Lolis, Elias J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893199/
https://www.ncbi.nlm.nih.gov/pubmed/35252348
http://dx.doi.org/10.3389/fmolb.2022.783669

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893199/
https://www.ncbi.nlm.nih.gov/pubmed/35252348
http://dx.doi.org/10.3389/fmolb.2022.783669

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