Simultaneous cellular and molecular phenotyping of embryonic mutants using single-cell regulatory trajectories

Developmental progression and cellular diversity are largely driven by transcription factors (TFs); yet, characterizing their loss-of-function phenotypes remains challenging and often disconnected from their underlying molecular mechanisms. Here, we combine single-cell regulatory genomics with loss-...

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Detalles Bibliográficos
Autores principales: Secchia, Stefano, Forneris, Mattia, Heinen, Tobias, Stegle, Oliver, Furlong, Eileen E.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893321/
https://www.ncbi.nlm.nih.gov/pubmed/35176234
http://dx.doi.org/10.1016/j.devcel.2022.01.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893321/
https://www.ncbi.nlm.nih.gov/pubmed/35176234
http://dx.doi.org/10.1016/j.devcel.2022.01.016

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