A genome-wide CRISPR screen identifies UFMylation and TRAMP-like complexes as host factors required for hepatitis A virus infection

Hepatitis A virus (HAV) is a positive-sense RNA virus causing acute inflammation of the liver. Here, using a genome-scale CRISPR screen, we provide a comprehensive picture of the cellular factors that are exploited by HAV. We identify genes involved in sialic acid/ganglioside biosynthesis and member...

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Detalles Bibliográficos
Autores principales: Kulsuptrakul, Jessie, Wang, Ruofan, Meyers, Nathan L., Ott, Melanie, Puschnik, Andreas S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893346/
https://www.ncbi.nlm.nih.gov/pubmed/33730579
http://dx.doi.org/10.1016/j.celrep.2021.108859

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893346/
https://www.ncbi.nlm.nih.gov/pubmed/33730579
http://dx.doi.org/10.1016/j.celrep.2021.108859

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