Selection of human single domain antibodies (sdAb) against thymidine kinase 1 and their incorporation into sdAb-Fc antibody constructs for potential use in cancer therapy

Thymidine Kinase 1 (TK1) is primarily known as a cancer biomarker with good prognostic capabilities for both hematological and solid malignancies. However, recent studies targeting TK1 at protein and mRNA levels have shown that TK1 may be useful as a therapeutic target. In order to examine the use o...

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Detalles Bibliográficos
Autores principales: Velazquez, Edwin J., Cress, Jordan D., Humpherys, Tyler B., Mortimer, Toni O., Bellini, David M., Skidmore, Jonathan R., Smith, Kathryn R., Robison, Richard A., Weber, Scott K., O’Neill, Kim L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893706/
https://www.ncbi.nlm.nih.gov/pubmed/35239730
http://dx.doi.org/10.1371/journal.pone.0264822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893706/
https://www.ncbi.nlm.nih.gov/pubmed/35239730
http://dx.doi.org/10.1371/journal.pone.0264822

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