Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader

Sliding clamps are ring-shaped protein complexes that are integral to the DNA replication machinery of all life. Sliding clamps are opened and installed onto DNA by clamp loader AAA+ ATPase complexes. However, how a clamp loader opens and closes the sliding clamp around DNA is still unknown. Here, w...

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Detalles Bibliográficos
Autores principales: Gaubitz, Christl, Liu, Xingchen, Pajak, Joshua, Stone, Nicholas P, Hayes, Janelle A, Demo, Gabriel, Kelch, Brian A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893722/
https://www.ncbi.nlm.nih.gov/pubmed/35179493
http://dx.doi.org/10.7554/eLife.74175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8893722/
https://www.ncbi.nlm.nih.gov/pubmed/35179493
http://dx.doi.org/10.7554/eLife.74175

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