Cargando…

Upstream open reading frames regulate translation of cancer-associated transcripts and encode HLA-presented immunogenic tumor antigens

BACKGROUND: Upstream open reading frames (uORFs) represent translational control elements within eukaryotic transcript leader sequences. Recent data showed that uORFs can encode for biologically active proteins and human leukocyte antigen (HLA)-presented peptides in malignant and benign cells sugges...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nelde, Annika, Flötotto, Lea, Jürgens, Lara, Szymik, Laura, Hubert, Elvira, Bauer, Jens, Schliemann, Christoph, Kessler, Torsten, Lenz, Georg, Rammensee, Hans-Georg, Walz, Juliane S., Wethmar, Klaus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894207/ https://www.ncbi.nlm.nih.gov/pubmed/35239002 http://dx.doi.org/10.1007/s00018-022-04145-0

Ejemplares similares

Somatic Functional Deletions of Upstream Open Reading Frame-Associated Initiation and Termination Codons in Human Cancer
por: Jürgens, Lara, et al.
Publicado: (2021)

The Peptide Vaccine of the Future
por: Nelde, Annika, et al.
Publicado: (2021)

Upstream open reading frames: Molecular switches in (patho)physiology
por: Wethmar, Klaus, et al.
Publicado: (2010)

HLA Evolutionary Divergence as a Prognostic Marker for AML Patients Undergoing Allogeneic Stem Cell Transplantation
por: Roerden, Malte, et al.
Publicado: (2020)

HLA-DR Presentation of the Tumor Antigen MSLN Associates with Clinical Outcome of Ovarian Cancer Patients
por: Tegeler, Christian M., et al.
Publicado: (2022)

Comprehensive translational control of tyrosine kinase expression by upstream open reading frames
por: Wethmar, K, et al.
Publicado: (2016)

Immunoprecipitation methods impact the peptide repertoire in immunopeptidomics
por: Wacker, Marcel, et al.
Publicado: (2023)

The Emerging Role of uORF-Encoded uPeptides and HLA uLigands in Cellular and Tumor Biology
por: Jürgens, Lara, et al.
Publicado: (2022)

Noise reduction by upstream open reading frames
por: Wu, Ho-Wei, et al.
Publicado: (2022)

Neoantigens in Hematological Malignancies—Ultimate Targets for Immunotherapy?
por: Roerden, Malte, et al.
Publicado: (2019)

Conserved upstream open reading frames in higher plants
por: Tran, Michael K, et al.
Publicado: (2008)

The role of upstream sequences in selecting the reading frame on tmRNA
por: Miller, Mickey R, et al.
Publicado: (2008)

Predicting functional upstream open reading frames in Saccharomyces cerevisiae
por: Selpi, et al.
Publicado: (2009)

A perspective on mammalian upstream open reading frame function
por: Somers, Joanna, et al.
Publicado: (2013)

Translational buffering by ribosome stalling in upstream open reading frames
por: Bottorff, Ty A., et al.
Publicado: (2022)

Antigen Targets for the Development of Immunotherapies in Leukemia
por: Bauer, Jens, et al.
Publicado: (2019)

Gene Expression Regulation by Upstream Open Reading Frames and Human Disease
por: Barbosa, Cristina, et al.
Publicado: (2013)

Translation of upstream open reading frames in a model of neuronal differentiation
por: Rodriguez, Caitlin M., et al.
Publicado: (2019)

Temperature-dependent regulation of upstream open reading frame translation in S. cerevisiae
por: Kulkarni, Shardul D., et al.
Publicado: (2019)

Posttranscriptional Regulation by Copper with a New Upstream Open Reading Frame
por: Roy, Gauthier, et al.
Publicado: (2022)

Integrative -omics and HLA-ligandomics analysis to identify novel drug targets for ccRCC immunotherapy
por: Reustle, Anna, et al.
Publicado: (2020)

HLA class I-restricted MYD88 L265P-derived peptides as specific targets for lymphoma immunotherapy
por: Nelde, Annika, et al.
Publicado: (2016)

The role of autologous stem cell transplantation (ASCT) in aggressive B-cell lymphomas: real-world data from a retrospective single-center analysis
por: Wullenkord, Ramona, et al.
Publicado: (2021)

Mass spectrometry-based identification of a B-cell maturation antigen-derived T-cell epitope for antigen-specific immunotherapy of multiple myeloma
por: Bilich, Tatjana, et al.
Publicado: (2020)

Immunopeptidome Diversity in Chronic Lymphocytic Leukemia Identifies Patients with Favorable Disease Outcome
por: Marconato, Maddalena, et al.
Publicado: (2022)

Long-Term Follow-Up of COVID-19 Convalescents—Immune Response Associated with Reinfection Rate and Symptoms
por: Seller, Anna, et al.
Publicado: (2023)

Conserved Peptide Upstream Open Reading Frames are Associated with Regulatory Genes in Angiosperms
por: Jorgensen, Richard A., et al.
Publicado: (2012)

Extensive Transcript Diversity and Novel Upstream Open Reading Frame Regulation in Yeast
por: Waern, Karl, et al.
Publicado: (2013)

Selective Constraint on the Upstream Open Reading Frames That Overlap with Coding Sequences in Animals
por: Hsu, Ming-Kung, et al.
Publicado: (2012)

A comprehensive catalog of predicted functional upstream open reading frames in humans
por: McGillivray, Patrick, et al.
Publicado: (2018)

Translational control of murine adiponectin expression by an upstream open reading frame element
por: Vasu, Kommireddy, et al.
Publicado: (2023)

Cancer testis antigen Cyclin A1 harbors several HLA-A*02:01-restricted T cell epitopes, which are presented and recognized in vivo
por: Teck, Anja Tatjana, et al.
Publicado: (2020)

Correction to: Cancer testis antigen Cyclin A1 harbors several HLA‑A*02:01‑restricted T cell epitopes, which are presented and recognized in vivo
por: Teck, Anja Tatjana, et al.
Publicado: (2021)

A profusion of upstream open reading frame mechanisms in polyamine-responsive translational regulation
por: Ivanov, Ivaylo P., et al.
Publicado: (2010)

An Upstream Open Reading Frame Modulates Ebola Virus Polymerase Translation and Virus Replication
por: Shabman, Reed S., et al.
Publicado: (2013)

Translation of the human erythropoietin transcript is regulated by an upstream open reading frame in response to hypoxia
por: Barbosa, Cristina, et al.
Publicado: (2014)

An Upstream Open Reading Frame Regulates LST1 Expression during Monocyte Differentiation
por: Schiller, Christian, et al.
Publicado: (2014)

uORF-Tools—Workflow for the determination of translation-regulatory upstream open reading frames
por: Scholz, Anica, et al.
Publicado: (2019)

Variation in upstream open reading frames contributes to allelic diversity in maize protein abundance
por: Gage, Joseph L., et al.
Publicado: (2022)

Elevated SARS-CoV-2-Specific Antibody Levels in Patients with Post-COVID Syndrome
por: Hackenbruch, Christopher, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ia9rdmssg8q5rh5jd4fafi1d2l