ASIC1a senses lactate uptake to regulate metabolism in neurons

Lactate is a major metabolite largely produced by astrocytes that nourishes neurons. ASIC1a, a Na(+) and Ca(2+)-permeable channel with an extracellular proton sensing domain, is thought to be activated by lactate through chelation of divalent cations, including Ca(2+), Mg(2+) and Zn(2+), that block...

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Detalles Bibliográficos
Autores principales: Azoulay, Ivana Savic, Qi, Xin, Rozenfeld, Maya, Liu, Fan, Hu, Qin, Ben Kasus Nissim, Tsipi, Stavsky, Alexandra, Zhu, Michael X., Xu, Tian-Le, Sekler, Israel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894274/
https://www.ncbi.nlm.nih.gov/pubmed/35247821
http://dx.doi.org/10.1016/j.redox.2022.102253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894274/
https://www.ncbi.nlm.nih.gov/pubmed/35247821
http://dx.doi.org/10.1016/j.redox.2022.102253

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