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ASIC1a senses lactate uptake to regulate metabolism in neurons
Lactate is a major metabolite largely produced by astrocytes that nourishes neurons. ASIC1a, a Na(+) and Ca(2+)-permeable channel with an extracellular proton sensing domain, is thought to be activated by lactate through chelation of divalent cations, including Ca(2+), Mg(2+) and Zn(2+), that block...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894274/ https://www.ncbi.nlm.nih.gov/pubmed/35247821 http://dx.doi.org/10.1016/j.redox.2022.102253 |