Spatiotemporal modulations in heterotypic condensates of prion and α-synuclein control phase transitions and amyloid conversion

Biomolecular condensation via liquid-liquid phase separation of proteins and nucleic acids is associated with a range of critical cellular functions and neurodegenerative diseases. Here, we demonstrate that complex coacervation of the prion protein and α-synuclein within narrow stoichiometry results...

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Detalles Bibliográficos
Autores principales: Agarwal, Aishwarya, Arora, Lisha, Rai, Sandeep K., Avni, Anamika, Mukhopadhyay, Samrat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894376/
https://www.ncbi.nlm.nih.gov/pubmed/35241680
http://dx.doi.org/10.1038/s41467-022-28797-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894376/
https://www.ncbi.nlm.nih.gov/pubmed/35241680
http://dx.doi.org/10.1038/s41467-022-28797-5

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