The neuronal-specific isoform of BIN1 regulates β-secretase cleavage of APP and Aβ generation in a RIN3-dependent manner

Genome-wide association studies have identified BIN1 (Bridging integrator 1) and RIN3 (Ras and Rab interactor 3) as genetic risk factors for late-onset Alzheimer’s disease (LOAD). The neuronal isoform of BIN1 (BIN1V1), but not the non-neuronal isoform (BIN1V9), has been shown to regulate tau-patholo...

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Detalles Bibliográficos
Autores principales: Bhattacharyya, Raja, Teves, Catarina Amelia Fidalgo, Long, Alexandra, Hofert, Madison, Tanzi, Rudolph E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894474/
https://www.ncbi.nlm.nih.gov/pubmed/35241726
http://dx.doi.org/10.1038/s41598-022-07372-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8894474/
https://www.ncbi.nlm.nih.gov/pubmed/35241726
http://dx.doi.org/10.1038/s41598-022-07372-4

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