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Flow synthesis of oxadiazoles coupled with sequential in-line extraction and chromatography
An efficient continuous flow process is reported for the synthesis of various 1,3,4-oxadiazoles via an iodine-mediated oxidative cyclisation approach. This entails the use of a heated packed-bed reactor filled with solid K(2)CO(3) as a base. Using DMSO as solvent, this flow method generates the targ...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895036/ https://www.ncbi.nlm.nih.gov/pubmed/35280956 http://dx.doi.org/10.3762/bjoc.18.27 |