Identification of Sclareol As a Natural Neuroprotective Ca(v)1.3‐Antagonist Using Synthetic Parkinson‐Mimetic Gene Circuits and Computer‐Aided Drug Discovery

Parkinson's disease (PD) results from selective loss of substantia nigra dopaminergic (SNc DA) neurons, and is primarily caused by excessive activity‐related Ca(2+) oscillations. Although L‐type voltage‐gated calcium channel blockers (CCBs) selectively inhibiting Ca(v)1.3 are considered promisi...

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Detalles Bibliográficos
Autores principales: Wang, Hui, Xie, Mingqi, Rizzi, Giorgio, Li, Xin, Tan, Kelly, Fussenegger, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895113/
https://www.ncbi.nlm.nih.gov/pubmed/35040584
http://dx.doi.org/10.1002/advs.202102855

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895113/
https://www.ncbi.nlm.nih.gov/pubmed/35040584
http://dx.doi.org/10.1002/advs.202102855

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