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Identification of Sclareol As a Natural Neuroprotective Ca(v)1.3‐Antagonist Using Synthetic Parkinson‐Mimetic Gene Circuits and Computer‐Aided Drug Discovery
Parkinson's disease (PD) results from selective loss of substantia nigra dopaminergic (SNc DA) neurons, and is primarily caused by excessive activity‐related Ca(2+) oscillations. Although L‐type voltage‐gated calcium channel blockers (CCBs) selectively inhibiting Ca(v)1.3 are considered promisi...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895113/ https://www.ncbi.nlm.nih.gov/pubmed/35040584 http://dx.doi.org/10.1002/advs.202102855 |