Smad4 Deficiency Promotes Pancreatic Cancer Immunogenicity by Activating the Cancer‐Autonomous DNA‐Sensing Signaling Axis

Smad4, a key mediator of the transforming growth factor‐β signaling, is mutated or deleted in 20% of pancreatic ductal adenocarcinoma (PDAC) cancers and significantly affects cancer development. However, the effect of Smad4 loss on the immunogenicity and tumor immune microenvironment of PDAC is stil...

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Detalles Bibliográficos
Autores principales: Xiong, Wenjing, He, Wenzhuo, Wang, Tiantian, He, Shuai, Xu, Feifei, Wang, Zining, Wang, Xiaojuan, Guo, Hui, Ling, Jianhua, Zhang, Huanling, Liu, Yongxiang, Xing, Kaili, Li, Mengyun, Zhang, Hongxia, Li, Jiahui, Niu, Ningning, Xue, Jing, Zhan, Qiuyao, Liu, Ze‐Xian, Bei, Jin‐Xin, Huang, Peng, Liu, Jinyun, Xia, Liangping, Xia, Xiaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895117/
https://www.ncbi.nlm.nih.gov/pubmed/35064757
http://dx.doi.org/10.1002/advs.202103029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895117/
https://www.ncbi.nlm.nih.gov/pubmed/35064757
http://dx.doi.org/10.1002/advs.202103029

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