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Targeting the RT loop of Src SH3 in Platelets Prevents Thrombosis without Compromising Hemostasis
Conventional antiplatelet agents indiscriminately inhibit both thrombosis and hemostasis, and the increased bleeding risk thus hampers their use at more aggressive dosages to achieve adequate effect. Blocking integrin αIIbβ3 outside‐in signaling by separating the β3/Src interaction, yet to be proven...
Autores principales: | Mao, Jianhua, Zhu, Kongkai, Long, Zhangbiao, Zhang, Huimin, Xiao, Bing, Xi, Wenda, Wang, Yun, Huang, Jiansong, Liu, Jingqiu, Shi, Xiaofeng, Jiang, Hao, Lu, Tian, Wen, Yi, Zhang, Naixia, Meng, Qian, Zhou, Hu, Ruan, Zheng, Wang, Jin, Luo, Cheng, Xi, Xiaodong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895158/ https://www.ncbi.nlm.nih.gov/pubmed/35023301 http://dx.doi.org/10.1002/advs.202103228 |
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