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Fragment-Based Drug Discovery by NMR. Where Are the Successes and Where can It Be Improved?

Over the last century, the definitions of pharmaceutical drug and drug discovery have changed considerably. Evolving from an almost exclusively serendipitous approach, drug discovery nowadays involves several distinct, yet sometimes interconnected stages aimed at obtaining molecules able to interact...

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Detalles Bibliográficos
Autores principales: Mureddu, Luca G., Vuister, Geerten W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895297/
https://www.ncbi.nlm.nih.gov/pubmed/35252355
http://dx.doi.org/10.3389/fmolb.2022.834453