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A Strategy to Select Macrocyclic Peptides Featuring Asymmetric Molecular Scaffolds as Cyclization Units by Phage Display

[Image: see text] Macrocyclic peptides (MPs) have positioned themselves as a privileged class of compounds for the discovery of therapeutics and development of chemical probes. Aided by the development of powerful selection strategies, high-affinity binders against biomolecular targets can readily b...

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Detalles Bibliográficos
Autores principales: Oppewal, Titia Rixt, Jansen, Ivar D., Hekelaar, Johan, Mayer, Clemens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895403/
https://www.ncbi.nlm.nih.gov/pubmed/35171585
http://dx.doi.org/10.1021/jacs.1c12822