KRAS mutation‐independent downregulation of MAPK/PI3K signaling in colorectal cancer

KRAS is a gatekeeper gene in human colorectal tumorigenesis. KRAS is ‘undruggable’; hence, efforts have been diverted to inhibit downstream RAF/MEK/ERK and PI3K/Akt signaling. Nevertheless, none of these inhibitors has progressed to clinical use despite extensive trials. We examined levels of phosph...

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Detalles Bibliográficos
Autores principales: Lam, Kuen Kuen, Tang, Choong Leong, Tan, Emile, Wong, Siew Heng, Cheah, Peh Yean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895447/
https://www.ncbi.nlm.nih.gov/pubmed/34919787
http://dx.doi.org/10.1002/1878-0261.13163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895447/
https://www.ncbi.nlm.nih.gov/pubmed/34919787
http://dx.doi.org/10.1002/1878-0261.13163

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