Inhibiting mutant KRAS G12D gene expression using novel peptide nucleic acid-based antisense: A potential new drug candidate for pancreatic cancer

KRAS mutations, which are the main cause of the pathogenesis of lethal pancreatic adenocarcinomas, impair the functioning of the GTPase subunit, thus rendering it constitutively active and signaling intracellular pathways that end with cell transformation. In the present study, the AsPC-1 cell line,...

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Detalles Bibliográficos
Autores principales: Shai, Ayelet, Galouk, Evleen, Miari, Reem, Tareef, Hala, Sammar, Marei, Zeidan, Mouhammad, Rayan, Anwar, Falah, Mizied
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895471/
https://www.ncbi.nlm.nih.gov/pubmed/35251350
http://dx.doi.org/10.3892/ol.2022.13250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895471/
https://www.ncbi.nlm.nih.gov/pubmed/35251350
http://dx.doi.org/10.3892/ol.2022.13250

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