Cargando…

Inhibiting mutant KRAS G12D gene expression using novel peptide nucleic acid-based antisense: A potential new drug candidate for pancreatic cancer

KRAS mutations, which are the main cause of the pathogenesis of lethal pancreatic adenocarcinomas, impair the functioning of the GTPase subunit, thus rendering it constitutively active and signaling intracellular pathways that end with cell transformation. In the present study, the AsPC-1 cell line,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shai, Ayelet, Galouk, Evleen, Miari, Reem, Tareef, Hala, Sammar, Marei, Zeidan, Mouhammad, Rayan, Anwar, Falah, Mizied
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895471/ https://www.ncbi.nlm.nih.gov/pubmed/35251350 http://dx.doi.org/10.3892/ol.2022.13250

Ejemplares similares

Indexing Natural Products for Their Potential Anti-Diabetic Activity: Filtering and Mapping Discriminative Physicochemical Properties
por: Zeidan, Mouhammad, et al.
Publicado: (2017)

Correlation between cytotoxicity in cancer cells and free radical-scavenging activity: In vitro evaluation of 57 medicinal and edible plant extracts
por: Sammar, Marei, et al.
Publicado: (2019)

Lauryl Gallate Activity and Streptococcus mutans: Its Effects on Biofilm Formation, Acidogenicity and Gene Expression
por: Gabe, Vika, et al.
Publicado: (2020)

Forty-One Plant Extracts Screened for Dual Antidiabetic and Antioxidant Functions: Evaluating the Types of Correlation between α-Amylase Inhibition and Free Radical Scavenging
por: Bashkin, Amir, et al.
Publicado: (2021)

A Novel Paclitaxel Conjugate with Higher Efficiency and Lower Toxicity: A New Drug Candidate for Cancer Treatment
por: Falah, Mizied, et al.
Publicado: (2019)

Inhibitory Effects of Ethyl Gallate on Streptococcus mutans Biofilm Formation by Optical Profilometry and Gene Expression Analysis
por: Gabe, Vika, et al.
Publicado: (2019)

A simple approach discriminating cardiosafe drugs from toxic ones
por: Falah, Mizied, et al.
Publicado: (2009)

Nature is the best source of anticancer drugs: Indexing natural products for their anticancer bioactivity
por: Rayan, Anwar, et al.
Publicado: (2017)

A Novel Docetaxel-Biotin Chemical Conjugate for Prostate Cancer Treatment
por: Rayan, Mahmoud, et al.
Publicado: (2022)

Alkyl Gallates as Potential Antibiofilm Agents: A Review
por: Rayan, Mahmoud, et al.
Publicado: (2023)

A New Approach for Indexing Honey for Its Heath/Medicinal Benefits: Visualization of the Concept by Indexing Based on Antioxidant and Antibacterial Activities
por: Masalha, Mahmud, et al.
Publicado: (2018)

Nanoscale Phytosomes as an Emerging Modality for Cancer Therapy
por: Kadriya, Ahmad, et al.
Publicado: (2023)

Increased serum level of alpha-2 macroglobulin and its production by B-lymphocytes in chronic lymphocytic leukemia
por: Michelis, Regina, et al.
Publicado: (2022)

Targeting oncogenic KRAS with molecular brush-conjugated antisense oligonucleotides
por: Wang, Dali, et al.
Publicado: (2022)

Prospects for Antisense Nucleic Acid Therapy of Cancer and AIDS
por: Tidd, D.M.
Publicado: (1993)

Suppressive Effects of Octyl Gallate on Streptococcus mutans Biofilm Formation, Acidogenicity, and Gene Expression
por: Gabe, Vika, et al.
Publicado: (2019)

Escaping KRAS: Gaining Autonomy and Resistance to KRAS Inhibition in KRAS Mutant Cancers
por: Adachi, Yuta, et al.
Publicado: (2021)

Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy
por: Xu, Ke, et al.
Publicado: (2019)

Extracellular vesicles mediated exocytosis of antisense peptide nucleic acids
por: Malik, Shipra, et al.
Publicado: (2021)

A combination therapy for KRAS-mutant lung cancer by targeting synthetic lethal partners of mutant KRAS
por: Pang, Xiufeng, et al.
Publicado: (2016)

Correction to: Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy
por: Xu, Ke, et al.
Publicado: (2020)

Defeat mutant KRAS with synthetic lethality
por: Pang, Xiufeng, et al.
Publicado: (2016)

Molecular dynamics simulations of acyclic analogs of nucleic acids for antisense inhibition
por: Galindo-Murillo, Rodrigo, et al.
Publicado: (2020)

A potent KRAS macromolecule degrader specifically targeting tumours with mutant KRAS
por: Bery, Nicolas, et al.
Publicado: (2020)

An ECM-Mimicking, Mesenchymal Stem Cell-Embedded Hybrid Scaffold for Bone Regeneration
por: Haj, Jozafina, et al.
Publicado: (2017)

Sequence motifs associated with hepatotoxicity of locked nucleic acid—modified antisense oligonucleotides
por: Burdick, Andrew D., et al.
Publicado: (2014)

Nucleic acid binding proteins affect the subcellular distribution of phosphorothioate antisense oligonucleotides
por: Bailey, Jeffrey K., et al.
Publicado: (2017)

Antimicrobial Activity of Peptide-Coupled Antisense Peptide Nucleic Acids in Streptococcus pneumoniae
por: Barkowsky, Gina, et al.
Publicado: (2022)

KRAS mutant colorectal tumors: Past and present
por: Brand, Toni M., et al.
Publicado: (2012)

Distinct metabolic preference of atypical KRAS mutant
por: Cheong, Heesun
Publicado: (2020)

Current therapy of KRAS-mutant lung cancer
por: Ghimessy, Aron, et al.
Publicado: (2020)

Small molecular inhibitors for KRAS-mutant cancers
por: Wu, Xuan, et al.
Publicado: (2023)

Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK
por: Wang, Jieqiong, et al.
Publicado: (2016)

Wild-Type KRAS Allele Effects on Druggable Targets in KRAS Mutant Lung Adenocarcinomas
por: Baldelli, Elisa, et al.
Publicado: (2021)

The intestinal microbiome, weight, and metabolic changes in women treated by adjuvant chemotherapy for breast and gynecological malignancies
por: Uzan-Yulzari, Atara, et al.
Publicado: (2020)

Selective targeting of KRAS-Mutant cells by miR-126 through repression of multiple genes essential for the survival of KRAS-Mutant cells
por: Hara, Toshifumi, et al.
Publicado: (2014)

MUC1-C confers EMT and KRAS independence in mutant KRAS lung cancer cells
por: Kharbanda, Akriti, et al.
Publicado: (2014)

Interference of ribosomal frameshifting by antisense peptide nucleic acids suppresses SARS coronavirus replication
por: Ahn, Dae-Gyun, et al.
Publicado: (2011)

Cooperative Cellular Uptake and Activity of Octaarginine Antisense Peptide Nucleic Acid (PNA) Conjugates
por: Ghavami, Mahdi, et al.
Publicado: (2019)

Drug discovery and development scheme for liver-targeting bridged nucleic acid antisense oligonucleotides
por: Wada, Fumito, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_tc9m1jvl68t1mmkgg089f92q7a