Enhancer promoter interactome and Mendelian randomization identify network of druggable vascular genes in coronary artery disease

Coronary artery disease (CAD) is a multifactorial disorder, which is partly heritable. Herein, we implemented a mapping of CAD-associated candidate genes by using genome-wide enhancer-promoter conformation (H3K27ac-HiChIP) and expression quantitative trait loci (eQTL). Enhancer-promoter anchor loops...

Descripción completa

Detalles Bibliográficos
Autores principales: Chignon, Arnaud, Mathieu, Samuel, Rufiange, Anne, Argaud, Déborah, Voisine, Pierre, Bossé, Yohan, Arsenault, Benoit J., Thériault, Sébastien, Mathieu, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895522/
https://www.ncbi.nlm.nih.gov/pubmed/35246263
http://dx.doi.org/10.1186/s40246-022-00381-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895522/
https://www.ncbi.nlm.nih.gov/pubmed/35246263
http://dx.doi.org/10.1186/s40246-022-00381-4

Ejemplares similares