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Enhancer promoter interactome and Mendelian randomization identify network of druggable vascular genes in coronary artery disease

Coronary artery disease (CAD) is a multifactorial disorder, which is partly heritable. Herein, we implemented a mapping of CAD-associated candidate genes by using genome-wide enhancer-promoter conformation (H3K27ac-HiChIP) and expression quantitative trait loci (eQTL). Enhancer-promoter anchor loops...

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Detalles Bibliográficos
Autores principales:	Chignon, Arnaud, Mathieu, Samuel, Rufiange, Anne, Argaud, Déborah, Voisine, Pierre, Bossé, Yohan, Arsenault, Benoit J., Thériault, Sébastien, Mathieu, Patrick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895522/ https://www.ncbi.nlm.nih.gov/pubmed/35246263 http://dx.doi.org/10.1186/s40246-022-00381-4

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