De novo generation of the NPM-ALK fusion recapitulates the pleiotropic phenotypes of ALK+ ALCL pathogenesis and reveals the ROR2 receptor as target for tumor cells

BACKGROUND: Anaplastic large cell lymphoma positive for ALK (ALK+ ALCL) is a rare type of non-Hodgkin lymphoma. This lymphoma is caused by chromosomal translocations involving the anaplastic lymphoma kinase gene (ALK). In this study, we aimed to identify mechanisms of transformation and therapeutic...

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Detalles Bibliográficos
Autores principales: Babin, Loélia, Darchen, Alice, Robert, Elie, Aid, Zakia, Borry, Rosalie, Soudais, Claire, Piganeau, Marion, De Cian, Anne, Giovannangeli, Carine, Bawa, Olivia, Rigaud, Charlotte, Scoazec, Jean-Yves, Couronné, Lucile, Veleanu, Layla, Cieslak, Agata, Asnafi, Vahid, Sibon, David, Lamant, Laurence, Meggetto, Fabienne, Mercher, Thomas, Brunet, Erika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895835/
https://www.ncbi.nlm.nih.gov/pubmed/35246138
http://dx.doi.org/10.1186/s12943-022-01520-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8895835/
https://www.ncbi.nlm.nih.gov/pubmed/35246138
http://dx.doi.org/10.1186/s12943-022-01520-0

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