CXCR3 regulates stem and proliferative CD8+ T cells during chronic infection by promoting interactions with DCs in splenic bridging channels

Production of effector CD8+ T cells during persistent infection requires a stable pool of stem-like cells that can give rise to effector cells via a proliferative intermediate population. In infection models marked by T cell exhaustion, this process can be transiently induced by checkpoint blockade...

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Detalles Bibliográficos
Autores principales: Bangs, Derek J., Tsitsiklis, Alexandra, Steier, Zoë, Chan, Shiao Wei, Kaminski, James, Streets, Aaron, Yosef, Nir, Robey, Ellen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8896093/
https://www.ncbi.nlm.nih.gov/pubmed/35045305
http://dx.doi.org/10.1016/j.celrep.2021.110266

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8896093/
https://www.ncbi.nlm.nih.gov/pubmed/35045305
http://dx.doi.org/10.1016/j.celrep.2021.110266

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