Allele-specific expression reveals genes with recurrent cis-regulatory alterations in high-risk neuroblastoma

BACKGROUND: Neuroblastoma is a pediatric malignancy with a high frequency of metastatic disease at initial diagnosis. Neuroblastoma tumors have few recurrent protein-coding mutations but contain extensive somatic copy number alterations (SCNAs) suggesting that mutations that alter gene dosage are im...

Descripción completa

Detalles Bibliográficos
Autores principales: Sen, Arko, Huo, Yuchen, Elster, Jennifer, Zage, Peter E., McVicker, Graham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8896304/
https://www.ncbi.nlm.nih.gov/pubmed/35246212
http://dx.doi.org/10.1186/s13059-022-02640-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8896304/
https://www.ncbi.nlm.nih.gov/pubmed/35246212
http://dx.doi.org/10.1186/s13059-022-02640-y

Ejemplares similares