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De novo mutation rates at the single-mutation resolution in a human HBB gene region associated with adaptation and genetic disease
Although it is known that the mutation rate varies across the genome, previous estimates were based on averaging across various numbers of positions. Here, we describe a method to measure the origination rates of target mutations at target base positions and apply it to a 6-bp region in the human he...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8896469/ https://www.ncbi.nlm.nih.gov/pubmed/35031571 http://dx.doi.org/10.1101/gr.276103.121 |