Blockade of the PD-1/PD-L1 Immune Checkpoint Pathway Improves Infection Outcomes and Enhances Fungicidal Host Defense in a Murine Model of Invasive Pulmonary Mucormycosis

Anecdotal clinical reports suggested a benefit of adjunct immune checkpoint inhibitors (ICIs) to treat invasive mucormycosis. However, proof-of-concept data in animal models and mechanistic insights into the effects of ICIs on host defense against Mucorales are lacking. Therefore, we studied the eff...

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Detalles Bibliográficos
Autores principales: Wurster, Sebastian, Albert, Nathaniel D., Bharadwaj, Uddalak, Kasembeli, Moses M., Tarrand, Jeffrey J., Daver, Naval, Kontoyiannis, Dimitrios P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8896628/
https://www.ncbi.nlm.nih.gov/pubmed/35251033
http://dx.doi.org/10.3389/fimmu.2022.838344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8896628/
https://www.ncbi.nlm.nih.gov/pubmed/35251033
http://dx.doi.org/10.3389/fimmu.2022.838344

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